Charles Liu, PhD, MD has been an integral member of the neurosurgery team at the Pickup Family Neurosciences Institute since 2014.  He currently serves as the Surgical Director of the Hoag Comprehensive Epilepsy Program.  In addition, he is the Director of Neurorestoration at Hoag, a program that brings together key platform technologies that operationalizes cutting-edge research concepts to clinical application to restore sensorimotor and cognitive neurological dysfunction for Hoag patients.  

Charles Liu completed his undergraduate education in chemical engineering at the University of Michigan, Ann Arbor and his PhD in chemical/bioengineering at Rice University.  He then attended medical school at Yale University before completing his neurosurgical training at the University of Southern California affiliated hospitals.  

Dr. Liu is engaged in a broad spectrum of efforts that brings together the fields of engineering and medicine to develop systems-level solutions to challenges that lead to human suffering due to loss of nervous system function over the life-span.  He is a recognized expert in complex intracranial surgery, epilepsy surgery, neurotrauma, and neurorehabilitation.  

He has also made key contributions in a large number of internationally visible “first-in-human” applications of transformative technologies to restore neurological function.  He is currently a professor of neurosurgery, neurology, urology, biomedical engineering, and physical therapy and biokinesiology at the University of Southern California, where he also serves as the Director of the USC Neurorestoration Center.  


He is also the Director of Neurorecovery Integrated Care Team and Chair of Neurosurgery and Orthopedics at Rancho Los Amigos National Rehabilitation Center.  He has had a long-standing association with Caltech, where he is appointed as visiting associate in Biology and Bioengineering.  

He has worked in close partnership with multiple private and public sector health systems to craft creative solutions to issues related to access to specialty services in underserved communities.  For example, he has provided principal leadership in the establishment of the USC Epilepsy Consortium, a unique patient-centered partnership for epilepsy care that connects over 20% of the National Association of Epilepsy Centers registered programs in California, including the first and only adult epilepsy center in Central California at Kern Medical in Bakersfield.  

He has made a large number of contributions to the published literature and delivered numerous key-note lectures nationally and internationally.  He serves as the Editor-in-Chief of the Journal of Clinical Neuroscience and directs a large number of collaborative research projects funded by federal and nonfederal agencies, including NIH, NSF, DARPA, and PAC-12 Conference.  He is also the Head Team Neurosurgeon for the USC Department of Athletics and is the neurosurgical consultant to the Rose Bowl Game. 

Patient Testimonials

What Our Patients Have To Say About Our Healthcare Services

“I’m very thankful for the wonderful staff and physicians at Hoag. I was treated extremely well and everyone seemed genuinely concerned about my well being.”

Susie Chew

“My memory and naming ability are awesome now. My husband said from the moment I woke up from surgery, ‘The old Tiffany is back.’ Dr. Millett and Dr. Liu are phenomenal. I am so grateful for the help they’ve given me.”

Tiffany Mueller

“By monitoring me almost every day, being flexible and responsive, Dr. Mehta gave me the confidence that doing the procedure was the right thing to do.” 

Tim Hsiao

Better Health Care is Our Mission

Concussions | Sleep | Epilepsy | Stroke | Neurodiagnostics | Neurophysiology


 520 Superior Ave, Suite #205 Newport Beach, CA 92663 

(949) 764-1843


16405 Sand Canyon Ave, 220
Irvine, CA 92618

(949) 336-8633


510 Superior Ave, Suite 200-A
Newport Beach, CA 92663